![]() ![]() DM1/HT rats showed a similar pro-fibrotic and pro-apoptotic state without inflammatory response. HT myocardium shared these features and showed, additionally, inflammatory cell infiltrate, with NF- κB activation, and expression of monocyte chemoattractant protein-1, and interleukins-1 β and -6, which were absent in DM1. Results: DM1 myocardium showed hypertrophy, fibrosis and apoptosis, with over-expression/activation of pro-fibrotic (transforming growth factor-β, connective tissue growth factor, linked transcription factors p-Smad3/4 and AP-1), and pro-apoptotic (Fas, Fas L, Bax, and cleaved caspase-3) factors. After 22 weeks, rats were killed and their left ventricles isolated for histological, biochemical, and proteomic (DIGE) and mass spectrometry assays. Vehicle-administrated rats were used as control. Methods: Normotensive and HT rats were injected 50 mg/kg streptozotocin to develop DM1. However, the effect of long-standing DM and of coexisting hypertension (HT) has not been studied.Īims: To study the myocardium of long-standing type I DM (DM1), HT and both pathologies (DM1/HT) analysing changes in protein expression by proteomic techniques. The acute effect of DM on the myocardium has been described. ![]() Customer Service and Ordering Informationīackground: Diabetes mellitus (DM) may affect directly the heart.Stroke: Vascular and Interventional Neurology.Journal of the American Heart Association (JAHA).Circ: Cardiovascular Quality & Outcomes.Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB). ![]()
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